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KMID : 0811719980020040503
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Korean Journal of Physiology & Pharmacology
1998 Volume.2 No. 4 p.503 ~ p.510
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Renal Handling of Sodium and Potassium in Cadmium Exposed Rats
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Yung Kyu Kim
Yang Saeng Park
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Abstract
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Effects of cadmium exposure on renal Na+ and K+ transports were studied in rats. During the course of cadmium treatment (2 mg Cd/kg/day, s.c. injections for 3 weeks) renal tubular transports of Na+ and K+ were evaluated by lithium clearance technique. During the early phase (first week) of cadmium treatment, urinary Na+ excretion decreased drastically and this was due to an increased Na+ reabsorption both in the proximal and distal nephrons. During the late phase (third week) of cadmium treatment, filtered Na+ load was decreased by reduction in GFR, but the renal Na+ excretion returned to the control level due to impaired Na+ transport in the proximal tubule. Urinary excretion of K+ did not change during the early phase, but it rose markedly during the late phase of cadmium treatment. These results indicate that a light cadmium intoxication induces a Na+ retention, and a heavy intoxication results in a K+ loss. Possible mechanisms for these changes are discussed.
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KEYWORD
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Cadmium, Renal function, Na, excretion, K, excretion, Lithium clearance,
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